RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
let-7i
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
homo sapiens
Detection Methods
PCR; immunohistochemistry etc.
Target
IL-6 COLLAGEN
Pathway
NA
PubMed ID
Title
MicroRNA Let-7i Negatively Regulates Cardiac Inflammation and Fibrosis
Year
2015
Function
Let-7i acts as a novel negative regulator of angiotensin ii-induced cardiac inflammation and fibrosis by suppressing the expression of interleukin-6 and multiple collagens in the heart.